[关键词]
[摘要]
目的 研究鄂西地区产冬凌草Isodon rubescens的化学成分。方法 采用多种柱色谱法进行分离纯化,并经波谱分析鉴定化合物的结构。结果 从湖北建始县产冬凌草的乙醇浸提物中,分离鉴定出6个对映-贝壳杉烷二萜,分别为3β,6β,14β,15β-四乙酰氧基-20-醛-对映-贝壳杉-16-烯-7-酮(1)、川藏香茶菜素O(2)、enmenin(3)、enmenin monoacetate(4)、乙酰化毛萼晶F(5)、荛花香茶菜乙素(6)。结论 化合物1为1个新化合物,命名为建始冬凌草素J,为香茶菜属植物极为少见的一类型对映-贝壳杉二萜,结构特点为C-20氧化为醛基而未与C-3、C-7、C-11形成常见的环氧桥结构。化合物2和4为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from Isodon rubescens collected in the west of Hubei Province. Methods Various column chromatography techniques were used to isolate and purify the compounds and their structures were identified by spectral data. Results From ethanol extract of plants in Jinshi County, six ent-kaurene diterpenoids were isolated and identified, of which one new compound 3β,6β,14β,15β-tetracetoxy-20-aldehyde-ent-kaur-16-en-7-one (1), and other known ones as pharicin O (2), enmenin (3), enmenin monoacetate (4), acetonide of maoyecrystal F (5), and wikstroenioidin B (6). Conclusion The new compound 1 named as jianshirubesin J is identified as a rare ent-kaurane diterpenoid in genus Isodon for its oxygenated C-20 as an aldehyde instead of a common epoxy-bridge with C-3, C-7, or C-11. And compound 2 and 4 are isolated from this plant for the first time.
[中图分类号]
R284.1
[基金项目]
湖北省自然科学基金(2020CFB616)