目的 研究野山参Panax ginseng根与根茎的化学成分。方法 利用HPD-400大孔吸附树脂和反相硅胶柱色谱以及半制备高效液相色谱等方法进行分离纯化，通过质谱、核磁共振波谱（¹H-和¹³C-NMR以及HSQC、HMBC实验）等手段鉴定化合物结构。结果 从野山参70%乙醇提取物经HPD-400大孔吸附树脂90%乙醇洗脱部位分离得到5个化合物，分别鉴定为8Z-癸烷-4，6-二炔-1-O-β-D-吡喃葡萄糖基-（1→2）-β-D-吡喃葡萄糖苷（1）、三七皂苷Rt（2）、20（E）-人参皂苷F₄（3）、人参皂苷Rg₆（4）、20（E）-人参皂苷Rg₉（5）。结论 化合物1为新的聚炔类化合物，命名为人参炔氧苷A；化合物2～5为首次从野山参中分离得到。

Objective To study the chemical constituents from the root and rhizome of wild ginseng (Panax ginseng). Methods HPD-400 macroporous resin column chromatography, reversed phase silica gel column chromatography, semi-preparative HPLC methods were used for separation and purification, and mass spectrometry, nuclear magnetic resonance spectroscopy (¹H-NMR, ¹³C-NMR, HSQC and HMBC) were analyzed to identify compound structures. Results Five compounds were isolated from the 90% ethanol fraction of the 70% ethanol extract eluated by HPD-400 macroporous absorption resin from the root and rhizome of wild ginseng, and elucidated as 8Z-decane-4,6-diyn-1-O-β-D-glucopyranosyl-(1-2)-β-D-glucopyranoside (1), notoginsenoside Rt (2), 20(E)-ginsenoside F₄ (3), ginsenoside Rg₆ (4) and 20(E)-ginsenoside Rg₉ (5). Conclusion Compound 1 is a new polyacetylene, named as panaxyneoside A. Compounds 2—5 are isolated from wild ginseng for the first time.

R284.1

国家重点研发计划项目（2017YFC1702302）