目的 运用高效液相色谱-四极杆-飞行时间质谱联用技术（HPLC-Q-TOF/MS），对六经头痛片中的化学成分进行分析鉴定。方法 采用Diamonsil C₁₈（250 mm×4.6 μm，5 μm）反相HPLC梯度洗脱法分离各主要成分，电喷雾电离源正负离子模式下对色谱流出物进行高分辨四级杆飞行时间串联质谱检测，对各主要色谱峰进行归属；同时结合化合物准确相对分子质量、质谱碎片离子信息及相关文献数据分析鉴定化合物。结果 通过质谱裂解规律结合自建的8味组方药材的化学成分库信息，共鉴定出95个化合物，主要包括异黄酮类、香豆素类、环烯醚萜类和苯酞类等成分，并对化合物的药材来源进行了归属。结论 采用HPLC-Q-TOF/MS联用技术比较全面地阐明了六经头痛片的化学组成，为其药效物质基础研究和质量控制提供了参考。

Objective To separate and identify the chemical constituents in Liujing Toutong Tablets (LTT) by HPLC-Q-TOF/MS. Methods The main components were separated by using the gradient elution method with RP-HPLC, Diamonsil C₁₈ (250 mm×4.6 μm, 5 μm). The positive and negative electro spray ionization (ESI) source was adopted for determine the chromatographic effluent, the main chromatographic peaks are assigned and distinguished by Q-TOF. These components were further analyzed by accurately relative molecular mass of compounds, and Combined with Positive and negative ions MS information and related literature data. Results According to the MS principle, the corresponding reference substances and literature datas, Ninety-five compounds of LTT were identified, mainly including isoflavones, coumarins, iridoids and phthalides. Furthermore, all of the constituents were surveyed and classified according to their medicinal materials derivation. Conclusion In this study, the main components in LTT were elucidated completely by HPLC-Q-TOF/MS. The results could provide the evidence for the research on active constituents and quality control of LTT.