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[摘要]
目的 研究半枝莲Scutellaria barbata地上部分的化学成分。方法 通过AB-8大孔吸附树脂、硅胶、聚酰胺和Sephadex LH-20柱色谱等多种手段进行分离,采用核磁共振等波谱技术对化合物结构进行鉴定。结果 从半枝莲95%乙醇提取物中分离鉴定了14个黄酮类化合物,分别为高车前素-7-O-β-D-葡萄糖醛酸甲酯(1)、芹菜素(2)、野黄芩苷(3)、野黄芩素(4)、木犀草素(5)、野黄芩苷甲酯(6)、异高山黄芩素-8-O-β-D-葡萄糖醛酸-6”-甲酯(7)、芹菜素-7-O-β-D-葡萄糖醛酸苷-6”-甲酯(8)、4'-羟基汉黄芩素(9)、5,4'-二羟基-6,7,3',5'-四甲氧基黄酮(10)、异高山黄芩素(11)、6-羟基木犀草素(12)、5-羟基-6,7,3',4'-四甲氧基黄酮(13)、三裂鼠尾草素(14)。结论 化合物7为首次从唇形科植物中分离得到,化合物1和13为首次从黄芩属植物中分离得到,化合物6和12为首次从半枝莲中分离得到。
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[Abstract]
Objective To investigate the constituents in the aerial parts of Scutellaria barbata. Methods The isolation and purification of the compounds were performed by AB-8 macroporous adsorption resin, silica gel, polyamide and Sephadex LH-20 column chromatography, and their structures were determined on physicochemical characters and spectroscopic data. Results Fourteen compounds were separated and elucidated as hispidulin-7-O-β-D-methylgluzcuronide (1), apigenin (2), scutellarin (3), scutellarein (4), luteolin (5), scutellarein-7-O-β-D-glucuronide methyl ester (6), isoscutellarein-8-O-β-D-glucuronide-6"-methyl ester (7), apigenin-7-O-β-D-glucuronide-6"-methyl ester (8), 4'-hydroxywogonin (9), 4',5-dihydroxy-3',5',6,7-tetramethoxyflavone (10), isoscutellarein (11), 6-hydroxyluteolin (12), 5-hydroxy-6,7,3',4'-tetramethoxyflavone (13), salvigenin (14). Conclusion Compound 7 is isolated from Lamiaceae for the first time, compounds 1 and 13 are for the first time isolated from the genus Scutellaria, and compounds 6 and 12 are for the first time obtained from S. barbata.
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