[关键词]
[摘要]
目的 研究裸蒴Gymnotheca chinensis的化学成分。方法 采用多种柱色谱及制备液相色谱分离纯化,经理化性质和波谱数据鉴定结构。结果 从裸蒴的甲醇提取物中分离得到16个化合物,分别鉴定为2-(1-羟基-4-羰基环己-2,5-二烯基)乙腈(1)、N-苯甲酰-2-羟基酪胺(2)、N-苯甲酰酪胺(3)、N-苯甲酰基-2-苯基乙胺(4)、7,4'-二甲氧基山柰酚(5)、蜜桔黄素(6)、桔皮晶(7)、姜黄酮A(8)、6-羟基大柱香波龙-4,7-二烯-3,9-二酮(9)、5,6-环氧-3-羟基大柱香波龙-7-烯-9-酮(10)、9-羟基大柱香波龙-4-烯-3-酮(11)、9-羟基大柱香波龙-4,7-二烯-3-酮(12)、黑燕麦内酯(13)、6β-羟基-豆甾-4-烯-3-酮(14)、6β-羟基-豆甾-4,22-二烯-3-酮(15)、3β-羟基-豆甾-5-烯-7-酮(16)。结论 化合物1和2为新的天然产物,其余化合物为首次从该特有属植物中分离得到。
[Key word]
[Abstract]
Objective To further study the chemical constituents of Gymnotheca chinensis. Methods The compounds were isolated and purified by silica gel column chromatography and preparative HPLC, and their structures were elucidated by spectral analysis. Results Sixteen compounds were isolated and identified as 2-(1-hydroxy-4-oxo-cyclohexa-2,5-dienyl)-acetonitrile (1), N-benzoyl-2-hydroxyltyramine (2), N-benzoyltyramine (3), N-benzoyl-2-phenylethylamine (4), 7,4'-dimethoxykaemferol (5), nobiletin (6), tangeretin (7), curculonone A (8), 6-hydroxy-4,7-megastigmadien-3,9-dione (9), 5,6-epoxy-3-hydroxy-7-megastigmen-9-one (10), 9-hydroxy-4-megastigmen-3-one (11), 9-hydroxy-4,7-megastigmadien-3-one (12), loliolide (13), 6β-hydroxy-stigmasta-4-en-3-one (14), 6β-hydroxy- stigmasta-4,22-dien-3-one (15), and 3β-hydroxy-stigmasta-5-ene-7-one (16). Conclusion Compounds 1 and 2 are new natural products, and the others are isolated from this genus for the first time.
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[基金项目]
国家自然科学基金资助项目(31560102);贵州省教育厅自然科学研究项目(黔教合KY字[2015]362)