[关键词]
[摘要]
目的 研究牛蒡子Fructus arctii花序苞片的化学成分。方法 采用硅胶柱色谱, 高效液相色谱及重结晶等方法进行分离纯化, 通过薄层色谱和波谱数据分析进行结构鉴定。结果 从牛蒡子花序苞片正己烷萃取物中分离得到12个化合物, 分别鉴定为胡萝卜苷(1)、isofouquierol(2)、(22E)-5α,8-表二氧麦角甾-6,22-二烯-3β-醇(3)、3β-hydroxy-21,22-epoxyursa-20 (30)-en(4)、3β,21β-二醇-20(30)-烯-蒲公英甾烷(5)、齐墩果酸(6)、牛蒡苷元(7)、carthamogenin(8)、咖啡酸(9)、4(14)-桉烯-8α,11-二醇(10)、monogynol A(11)、羽扇豆醇(12)。结论 化合物2、3、5、6、10、11为首次从该属植物中分离得到, 化合物12为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the inflorescence bracts of Arctii Fructus. Methods The compounds were isolated and purified by the methods of silica gel column chromatography, HPLC, and recrystallization, and the structures were elucidated by the means of spectral analysis. Results Twelve compounds were isolated and identified as daucosterol (1), isofouquierol (2), (22E)-5α,8-epidioxyergosta-6,22-dien-3β-ol (3), 3β-hydroxy-21,22-epoxyursa-20(30)-en (4), 3β,21β-dihydroxy-20(30)-en-taraxastane (5), oleanolic acid (6), arctigenin (7), carthamogenin (8), caffeic acid (9), 4(14)-eudesmene-8α,11-diol (10), monogynol A (11), and lupeol (12). Conclusion Compounds 2—3, 5, 6, 10—11 are obtained from the plants of Arctium L. for the first time, and compound 12 is isolated from the inflorescence bracts of Arctii Fructus for the first time.
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[基金项目]
教育部留学回国人员科研启动基金(教外司留 [2011] 1139号-42);黑龙江省博士后资助经费项目(LBH-Z10234)