Abstract
Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.
摘要
心血管疾病(CVDs)在全球范围内是死亡的主要驱动因素. 铁是一种必需的微量元素, 在多种生物过程中很重要. 几十年来, 铁对心血管疾病的作用引起了广泛的讨论. 由铁介导的细胞死亡方式, 即铁死亡, 在心肌细胞损伤和心血管疾病中发挥着重要的作用, 因此受到广泛关注. 此外, 铁自噬是诱导铁死亡的上游机制, 与心血管疾病密切相关. 本文就铁死亡和铁自噬的过程、 机制、 铁自噬的调控途径和分子靶点进行综述, 并总结其对心血管疾病的作用. 此外, 我们讨论了针对铁自噬诱导的铁死亡调节剂治疗心血管疾病的可能性. 总之, 本综述将为心血管疾病的病理学机制提供新的见解, 并提供一系列潜在治疗靶点.
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (Nos. 82204389 and 82000454), the Medical Science and Technology Research Project of Henan Province (No. SBGJ202103079), and the Henan Medical Science and Technology Joint Building Program (Nos. LHGJ20230283, LHGJ20190236, LHGJ20190227, LHGJ20190092, LHGJ20200310, and LHGJ20200284), China. We thank the Home for Researchers (https://www.home-for-researchers.com) for their language modification service.
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Yi LUAN contributed to the conception of the study. Yi LUAN and Yang YANG contributed significantly to data analysis and manuscript preparation. Yang YANG, Kaidi REN, Bo QIN, and Hengdao LIU wrote the manuscript. Kaidi REN, Bo QIN, Hengdao LIU, Yi LUAN, and Yang YANG provided ideas and financial support for the review. Ying LUAN, Hui LIU, Han XING, and Jinyan PEI helped perform the analysis with constructive discussion and provided substantive guidance on the paper’s ideas and the entire writing process. All authors have read and approved the final manuscript.
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Yi LUAN, Yang YANG, Ying LUAN, Hui LIU, Han XING, Jinyan PEI, Hengdao LIU, Bo QIN, and Kaidi REN declare that they have no conflict of interest.
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Luan, Y., Yang, Y., Luan, Y. et al. Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases. J. Zhejiang Univ. Sci. B 25, 1–22 (2024). https://doi.org/10.1631/jzus.B2300097
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DOI: https://doi.org/10.1631/jzus.B2300097