Expression of Caspase-9,Caspase-3 and Bcl-2 Protein in Skin Scar CarcinomaChinese Full Text
MA Na;GUO Rui-zhen;Pathology Department of Zhuhai Campus of Zunyi Medical College;
Abstract: Objective To explore the association of cell apoptosis markers including Caspase-9,Caspase-3 and Bcl-2in scar carcinoma. Methods Using 10 normal skin epidermis as control,we observed 15 pathological scar epithelium and 20 skin scar carcinoma tissues. The expression of Caspase-9,Caspase-3 and Bcl-2 were detected by immunohistochemical staining technique（ SP）. Apoptotic bodies were detected by terminal eoxynucleotidyltransferase（ TdT）-mediated dUTP nick end labeling（ TUNEL）. Results Caspase-9 showed negative expression in normal skin epidermis and pathological skin scar epithelium,but weakly positive expression in scar carcinoma. Caspase-3 showed positive expression in normal skin epidermis and pathological skin scar epithelium,but weakly positive expression in scar carcinoma group. The expression level and intensity of scar carcinoma group was significantly different from the pathological skin scar group and the normal skin group（ P ＜ 0. 01）. No significant difference of expression level between the normal skin group and the pathological skin scar group（ P ＞ 0. 05） were observed. Bcl-2 showed negative expression in scar carcinoma tissue,and weak expression in basal cell layer and prickle cell layer of normal skin epidermis and pathological scar epithelium. The expression differences were not significant between different groups（ P ＞ 0. 05）. Apoptotic index of the normal skin and the pathological skin scar group was significantly higher than the scar carcinoma group（ P ＜ 0. 05）. However,there was no significant difference of apoptotic index between the normal skin group and the pathological skin scar group（ P ＞ 0. 05）. Conclusion The occurrence of scar carcinoma is related to the inhibition of cell apoptosis,which may be associated with the decreased expression of Caspase-9 and Caspase-3,but unrelevant to Bcl-2 anti-apoptotic effect.
Keywords：
- DOI：
10.13735/j.cjdv.1001-7089.2014.0776
- Series：
- Subject：
- Classification Code：
R739.5
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