Baicalein Inhibits Doxorubicin-Induced Inflammation and Cytotoxicity in Rat Cardiomyocytes by Modulating Activation of NF-κB and JNK PathwayChinese Full Text
DAI Yuan;HU Yong;JU Shao-hua;Chengdu University of TCM;
Abstract: Objective: To investigate whether Baicalein attenuates doxorubicin（ DOX）-induced inflammation and cytotoxicity in rat cardiomyocytes by modulating nuclear factor κB（ NF-κB） and c-jun N terminal kinase（ JNK） pathway. Methods: The expression of NF-κB p65 and JNK was measured by western blotting. Results: Treatment of cardiomyocytes with DOX significantly upregulated the expression level of phosphorylated NF-κB p65（ p-p65） and JNK,as well as a decrease in cell viability. Co-treatment with Baicalein depressed the up-regulation of p-p65 and JNK expression induced by DOX. Conclusion: Baicalein may protect cardiomyocytes against DOX-induced inflammatory response and cytotoxicity by inhibiting NF-κB and JNK pathway.
- DOI：
10.13593/j.cnki.51-1501/r.2014.02.026
- Series：
- Subject：
- Classification Code：
R285.5
- Mobile Reading
Read on your phone instantly
Step 1Scan QR Codes
"Mobile CNKI-CNKI Express" App
Step 2Open“CNKI Express”
and click the scan icon in the upper left corner of the homepage.
Step 3
Scan QR Codes
Read this article on your phone.
- HTML
- CAJ Download
- PDF Download
Download the mobile appuse the app to scan this coderead the article.
Tips: Please download CAJViewer to view CAJ format full text.
Download: 215 Page: 26-28 Pagecount: 3 Size: 535K
Citation Network
Related Literature
- Similar Article
- Reader Recommendation
- Associated Author