Clinical study of intravenous chemotherapy and intraperitoneal chemotherapy combined with thermal therapy in treating patients with advanced gastric cancer with malignant ascites.Chinese Full Text
HUI Hong-xia;WAN Yi-yuan;WANG Xiao-wei;Huai’an First People’s Hospital Affiliated To Nanjing Medical University;
Abstract: Objective To evaluate the clinica1 efficiency and toxicity of intravenous chemotherapy combined with intraperitoneal chemotherapy and thermal therapy in treating advanced gastric cancer patients with malignant ascites. Methods Fifty-six patients with advanced gastric caner with malignant ascites received a combination chemotherapy that used intravenous chemotherapy of docetaxol 75 mg /m2 IV drip dl and 5-Fu 2. 5 g /m2 CIV drip for 120 h,intraperitoneal chemotherapy（ DDP 40 mg /m2d1,d8） and thermal therapy,repeated every 3 weeks。Results Among 56 patients,complete response 12 case,partial response23 cases,in which the tota1 response rate was 62. 5%. Median time to progression was 8. 7 months,median survival time was 13. 4 months. The main toxicities included myelosuppression,gastrointestinal reaction and mucositis. Conclusion Intravenous chemotherapy combined with intraperitoneal chemotherapy and thermal therapy were effective in treating patients with advanced gastric cancer with malignant ascitesr,the toxicity is mild and tolerable for most patients.
Keywords：
Advanced gastric cancer; Malignant ascites; Intravenous chemotherapy; Intrap-eritoneal chemotherapy; Thermal therapy;
- DOI：
10.13455/j.cnki.cjcor.2014.08.17
- Series：
- Subject：
- Classification Code：
R735.2
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