The clinical efficacy of recombinant human endostatin combined with vinorelbine and cisplatin for the treatment of ⅢB-Ⅳ stage non-small cell lung cancerChinese Full Text
XIONG De-ming;REN Bi-yong;ZHU Chuan;Department of Oncology ward 2,Chongqing Sanxia Central Hospital;
Abstract: Objective To investigate the recent clinical efficacy of recombinant human endostatin combined with vinorelbine and cisplatin for the treatment of Ⅲ B-Ⅳ stage non-small cell lung cancer（ NSCLC）. Methods 58 cases of patients with ⅢB-Ⅳ stage NSCLC were divided into the control group（ n =28） and the observation group（ n =30） according to the random number table. The control group were received the treatment of vinorelbine and cisplatin,the observation group were given recombinant human endostatin on the basis of the control group. The recently total effective rate,clinical benefit rate,quality life improvement,serum carcinoembryonic antigen（ CEA） and the changes in incidence of adverse reactions of the two groups were compared. Results The effective rate,clinical benefit rate and quality life improvement rates were 33. 3%,73. 3% and 73. 3%,which were all higher than those of the control group（ 14. 3%,60. 1% and 35. 7%）（ all P ＜0. 05）. The CEA level of the observation group were higher than that of the control group（ 15. 99 ± 6. 39 vs 32. 60 ± 5. 61）（ P ＜ 0. 05）. Ana no significant difference of the incidence of adverse reactions of the two groups was found（ P ＞ 0. 05）. Conclusion Recombinant human endostatin combined with vinorelbine and cisplatin can improve patients’ treatment efficiency,clinical benefit rate and quality of life for the treatment of ⅢB-Ⅳ non-small cell lung cancer,which has better synergy and security and is worthy of application.
Keywords：
Carcinoma,non-small cell lung; Recombinant human endostatin; Vinorelbine; Cisplatin; Efficacy;
- DOI：
10.13455/j.cnki.cjcor.2014.06.13
- Series：
- Subject：
- Classification Code：
R734.2
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