Effect of PRRSV Infection on IFI30 Gene Expression in PAMChinese Full Text
LI Chuan-min;ZHANG Xiao-jun;GUO Jiang;DING Zhuang;ZHAO Zhi-hui;SUN Bo-xing;College of Animal Science, Jilin University;College of Animal Medicine, Jilin University;
Abstract: Interferon, gamma-inducible protein 30（IFI30）plays a key role in MHC classⅡ-restricted antigen processing and MHCⅠ-restricted cross-presentation. In our study, PAMs were infected by PRRSV of three different concentrations, and the levels of IFI30 mRNA expression of different time were detected by qPCR. The results showed that the IFI30 expression differences were not significant when PAMs were infected by three different concentrations,0.08 MOI,0.10 MOI and 0.12 MOI（P＞ 0.05）, respectively. The expression of IFI30 infected by PRRSVafter1.5 hwas reduced,butthe difference was not significant（P＞ 0.05）, and then the expression of IFI30 was increased, the expression difference was very significantwhen PAMs were infected by PRRSV after 12 h, 24 h and 36 h（P＜ 0.01）, but then the expression of IFI30 was reduced（P＜ 0.05）. The results indicated that the IFI30 expression change in the process of PRRSV infecting PAM may be one of the mechanisms which interact between PRRSV and host.
Keywords：
- DOI：
10.13327/j.jjlau.2014.1878
- Series：
- Subject：
- Classification Code：
S852.651
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