Knowledge Network Node
Chinese Journal of Hospital Pharmacy. 2014, (20) Core

Efficacy and safety of ceftriaxone plus metronidazole for treating complicated intra-abdominal infections:a Meta-analysisChinese Full Text

PAN Di-yi;HUANG Feng-tin;CUI Bo;ZHANG Wei-cun;The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine;Border Armed Police Corps Hospital of Guangdong Province;

Abstract: OBJECTIVE To evaluate the efficacy and safety of ceftriaxone plus metronidazole for treatment of complicated intraabdominal infections.METHODS Pubmed,Science Direct,Clinical trials.gov,Cochrane library,CNKI and CBM were searched to retrieve randomized controlled trials（RCTs） compared ceftriaxone plus metronidazole with other antibiotics in the treatment of complicated intra-abdominal infections（last search time:December 30 th,2013）.Meta-analysis was performed with the RevMan 5.2 software supplied by Cochrane Collaboration.RESULTS Eight randomized controlled trials included a total of 3214 patients with complicated intra-abdominal infections were included for Meta-analysis.The results of the Meta-analysis indicated that the group of ceftriaxone /metronidazole combination was as good as the control group,with similar clinical cure rate（eight RCTs,2736 patients,OR = 1.04,95%CI:0.84-1.30,P = 0.72）,bacteriological success rate（seven RCTs,1814 patients,OR = 1.04,95% CI:0.80-1.36,P = 0.76）;The overall incidence of adverse events（six RCTs,2159 patients,OR = 0.89,95% CI:0.74-1.07,P = 0.20）,serious adverse events（six RCTs,2410 patients,OR = 0.79,95% CI:0.62-1.01,P = 0.06）,drug-related adverse events（six RCTs,2276 patients,OR = 0.88,95% CI:0.67-1.15,P = 0.34） and mortality（seven RCTs,2853 patients,OR = 0.90,95% CI:0.60-1.36,P =0.63） of ceftriaxone /metronidazole combination group were also similar between the compared treatment groups.CONCLUSION Ceftriaxone / metronidazole combination can be used as effectively and safely,as other recommended antimicrobial regimens,for the treatment of complicated intra-abdominal infections.
Keywords：

ceftriaxone; metronidazole; complicated intra-abdominal infections; efficacy; safety; Meta-analysis;

  • DOI：

    10.13286/j.cnki.chinhosppharmacyj.2014.20.18

  • Series：

  • Subject：

  • Classification Code：

    R656

  • Mobile Reading
    Read on your phone instantly
    Step 1

    Scan QR Codes

    "Mobile CNKI-CNKI Express" App

    Step 2

    Open“CNKI Express”

    and click the scan icon in the upper left corner of the homepage.

    Step 3

    Scan QR Codes

    Read this article on your phone.

  • HTML
  • CAJ Download
  • PDF Download

Download the mobile appuse the app to scan this coderead the article.

Tips: Please download CAJViewer to view CAJ format full text.

Download: 343 Page: 1764-1769 Pagecount: 6 Size: 562K

Related Literature
  • Similar Article
  • Reader Recommendation
  • Associated Author