Effects of antioxidation and vascular morphology of ultrafiltrating substances of Astragalus and Hedysarumin hypertensive ratsChinese Full Text
WANG Zhi-wang;LIU Yong-qi;WEI Shu-chang;YAN Chun-lu;WANG Rui-qiong;Gansu College of Chinese Medicine;Gansu University of Chinese Medicine,Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities;Key Laboratory of Dunhuang Medicine and Trasformation of Ministry of Education;
Abstract: OBJECTIVE To study the antihypertensive effects of ultrafiltrating substances of Astragalus and Hedysarumin hypertensive rats and the mechanism of actions from antioxidant direction.METHODS The salt hypertension rats were replicated,the blood pressure,vascular morphology,antioxidant enzymes and oxidation products were observed to test the antihypertensive effect and its mechanism of action.RESULTS 1.32 g·kg-1 Astragalus ultrafiltrating substances and 1.68 g·kg-1Hedysarumultrafiltrating substances inhibited obviously the abnormal thickening of the aortic vessel wall,ascension of blood pressure and the decrease in body weight.Both of them increased SOD and GSH-PX activity and decreased the level of MDA in the serum（P＜0.05,0.01）.CONCLUSION The ultrafiltrating substances of Astragalusand Hedysarumhave a certain hypotensive effects and have no significant difference between the two ones.Exaltation of antioxidant capacity and relief of vascular remodeling are the mechanisms of their antihypertension.
Keywords：
Astragalus ultrafiltrating substances; Hedysarumultrafiltrating substances; hypertensive rats; antioxidation; vascular remodeling;
- DOI：
10.13286/j.cnki.chinhosppharmacyj.2014.19.09
- Series：
- Subject：
- Classification Code：
R285.5
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