Effect of compatibility with paeoniflorin on the accumulation of diester-type alkaloids of Fuzi in rat’s bodyChinese Full Text
XIONG Wen-hai;ZHENG Qin;HU Shuang;ZHOU Huan;XUE Xin;YANG Jia-liu;YU Jin;YANG Ming;Key Lab of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Traditional Chinese Medicine;Chengdu University of Traditional Chinese Medicine;
Abstract: OBJECTIVE To study the effect of compatibility with paeoniflorin on the accumulation of diester-type alkaloids,which are active ingredients of Radix Aconiti Carmichaeli Praeparata.METHODS Rats were gavaged with aconitine,mixture of aconitine and paeoniflorin,mesaconitine,mixture of mesaconitine and paeoniflorin,hypaconitine,mixture of hypaconitine and paeoniflorin respectively.Concentrations of three diester-type alkaloids in heart,liver and kidney were detected by LC-MS.Differences between before and after compatibility with paeoniflorin were observed.RESULTS The concentration of aconitine in heart decreased,concentrations of mesaconitine and hypaconitine in heart,liver and kidney all decreased after compatibility with paeoniflorin.CONCLUSION The accumulation of diester-type alkaloids can be reduced by paeoniflorin,especially the concentration in heart,which indicated that the cardiotoxicity of Fuzi can be restricted by paeoniflorin.
Keywords：
aconitine; meseacontine; hypaconitine; paeoniflorin; accumulation; compatibility rationality;
- DOI：
10.13286/j.cnki.chinhosppharmacyj.2014.18.02
- Series：
- Subject：
- Classification Code：
R285.5
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