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Chinese Journal of Hospital Pharmacy. 2014, (16) Core

Analysis on the efficacy of TEC regimen as neoadjuvant chemotherapy in advanced breast cancer（NCT）Chinese Full Text

LIU Li-juan;LAI Yan-wei;Department of Pharmacy,Shenzhen Hospital,Peking University;

Abstract: OBJECTIVE To observe the effects of taxotere+cytoxan+epirubicin in advanced breast cancer as neoadjuvant chemotherapy.METHODS 58 cases of women with advanced breast cancer patients were enrolled into this study.28（50%）cases of patients were not suitable for operation（phase T4 or inflammatory cancer）.The average tumor size was 8 cm.32 patients（63%）had estrogen receptor positive tumors and 10 patients（18%）had tumors with HER2 overexpression.TEC（taxotere+cytoxan+epirubicin）for NCT was docetaxel 75 mg·m-2,CTX（cyclophosphamide）500 mg·m-2,EPI（epirubicin）60 mg·m-2,through intravenous,every28 days as a course of treatment.They accepted total of 4 chemotherapy before preoperative treatment.RESULTS After neoadjuvant chemotherapy,all patients were operated.Pathology of breast achieved complete remission（pCR）in16 patients（28%）and 12 cases（21%）reached the breast and axillary lymph node pCR.All patients had completed chemotherapy scheduled,the common side effects including hair loss and anemia.CONCLUSION Neoadjuvant chemotherapy with TEC for local advanced breast cancer,even for greater tumor and non HER2 positive patients,has a good effect and well tolerated.TEC regimen could be worthy for clinical use in advanced breast cancer.
Keywords：

breast cancer; neoadjuvant chemotherapy; docetaxel;

  • DOI：

    10.13286/j.cnki.chinhosppharmacyj.2014.16.16

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  • Classification Code：

    R737.9

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