Preparation and in-vitro release of Yixintong osmotic pump tabletsChinese Full Text
LU Li;LIU Hui;YANG Chu-hao;ZHANG Yun;DU Sheng-nan;Clinical Medicine college in Wuhan,Southern Medical University;Department of Pharmacy,Wuhan General Hospital of Guangzhou Military Command;College of Pharmacy,Hubei University of Chinese Medicine;
Abstract: OBJECTIVE To study the preparation and in-vitro release of Yixintong osmotic pump tablets.METHODS The method for determination of drug release was established.The single factor test that affected drug release in vitro was established.The single factor test that affected drug release in vitro was investigated to optimize the prescriptions of two-layer core and coated member,respectively.The similarity factors f2 were used to evaluate the similarities of the drug release profiles. RESULTS Drug release profiles in vitro were obviously affected by the content of PEO and NaCl in the push layer and membrane thickness,but relatively lesser with agents in the drug layer and the release conditions in vitro.The drug release profile in vitro of optimized prescription of Yixintong osmotic pump tablets fits zero-order model.The equation was:Q=6.304 1t+ 5.937 2（r=0.993 1）.CONCLUSION The prepared Yixintong osmotic pump tablets with osmotic pump technique was prominent in the characteristics of controlled release,not only could it be used for the study of preparation of Yxintong controlled release,but also provided a new idea for the modernization of Chinese traditional drug formulation.
Keywords：
Yixintong; two-layer osmotic pump tablets; in-vitro release; f2factors; single factor tests;
- DOI：
10.13286/j.cnki.chinhosppharmacyj.2014.11.07
- Series：
- Subject：
- Classification Code：
R943
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