Study on the main pharmacodynamics and acute toxicity of Niuhuang Qingzhi suppositoryChinese Full Text
CHEN Hui-hua;LI Zhong-peng;WANG Bin-bin;Wuhan Hospital of Traditional Chinese Medicine;
Abstract: OBJECTIVE To investigate the main pharmacodynamics and acute toxicity of Niuhuang Qingzhi suppository. METHODS Animal models,such as xylene-induced ear edema,acetic acid-induced local ulcer,analgesia on hot-plate test,tail bleeding time in mice assay,were employed to evaluate the main pharmacodynamic effects of Niuhuang Qingzhi suppository.In vitro antibacterial test and the acute toxicity were also studied.RESULTS Niuhuang Qingzhi suppository possessed strong bacteriostatic and bactericidal effects,and could obviously relieve ear edema,promote local ulcer healing,increase pain threshold and shorten tail bleeding time in mice.CONCLUSION Niuhuang Qingzhi suppository possessed effects of antibacterial,antiinflammatory,ulcer repair promoting,analgesic,hemostasis,and minor toxicity.
- DOI：
10.13286/j.cnki.chinhosppharmacyj.2014.10.09
- Series：
- Subject：
- Classification Code：
R285.5
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