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Study on the anti-inflammatory and expectorant effects of volatile oil from Nigella Glandulif-eraChinese Full Text

GENG Dong-sheng;WANG Xue-fei;CHEN Xue-lian;Institute for Drug and Instrument Control of Xinjiang Military Command;Xinjiang Medical University;

Abstract: OBJECTIVE To investigate the anti-inflammatory and expectorant effects of volatile oil from Nigella glandulifera( VONG) for the first time. METHODS The carrageenan-induced paw edema in mice and cotton ball induced granuloma experiments were employed to evaluate the anti-inflammatory effect; a mouse model of phenol red test and the rabbit tracheal ciliary mucus flow promotion experiments were employed to evaluate the expectorant effect. RESULTS The experimental results showed that the different dose group of VONG could significantly inhibit carrageenan-induced mouse paw swelling degree and the hyperplasia of granulation tissue in rats( P < 0. 01); increase phenol red excretion in mice and rabbit tracheal ciliary mucus flow velocity( P < 0. 01). CONCLUSION The results indicated that VONG has some anti-inflammatory and expectorant activities.
  • DOI:

    10.13286/j.cnki.chinhosppharmacyj.2014.08.03

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  • Classification Code:

    R285.5

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