Efficacy and safety of S-1 for advanced gastric cancer:a systematic reviewChinese Full Text
DAI Zhu;HU Meng-tian;ZHU Hong-da;First Affiliated Hospital of Yangtze University;School of Food and pharmaceutical Engineering,Hubei University of Technology;
Abstract: OBJECTIVE To assess the efficacy and safety of S-1in treating advanced gastric cancer.METHODS The Cochrane library,MEDLINE,Elsevier,CNKI databases were searched,randomized controlled trails（RCT）about S1for advanced gastric cancer were evaluated and analyzed by RevMan5.2.RESULTS 10RCTs were enrolled in the Meta-analysis.The S-1 group had a higher the disease control rate than the control group[OR=1.9,95%CI（1.27,2.85）,P=0.002].Compared with the surgery-only group,the S-1group had a higher rate of overall survival at 3years（P=0.0002）and at 5years（P=0.002） than in the surgery-only group.Significant safety advantages were observed in the S-1group,the hematological system（grade 3/4）in the incidence of adverse reactions significant decreased comparing with the control group.There were no significant differences at digestive system,stomatitis in the incidence of adverse reactions.CONCLUSION S-1showed good efficacy in the treatment advanced gastric carcinoma,and the adverse reactions were relatively mild.So S1is the better choice for the treatment of advanced gastric cancer.
- DOI：
10.13286/j.cnki.chinhosppharmacyj.2014.07.15
- Series：
- Subject：
- Classification Code：
R735.2
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