Effects of the cryptotanshinone on aspirin esterase in rat liver microsomesChinese Full Text
XIE Song;YU Zong-qin;XU Ji-ping;Department of Pharmacy,Shandong Provincial Hospital affiliated to Shandong University;Shandong Medical College;
Abstract: OBJECTIVE To study the effects of cryptotanshinone on the aspirin esterase in rat liver microsomes.METHODS The concentrations of aspirin and it’s metabolite（salicylic acid）in the culture in vitro were determined by RP-HPLC.The concetrations ratio of CASA /（CASA +CSA）was used to reflect the activity of aspirin esterase in rat liver microsomes.The impact of cryptotanshinone on aspirin esterase in rat liver microsomes was evaluated by comparing aspirin esterase activities betweencontrol group and experimental group.RESULTS Cryptotanshinone decreased aspirin esterase activity（P＜0.05）.The double reciprocal regression of Lineweaver-Burk showed that the experimental group’s Vmax was essentially the same,and Km become gradually larger with the increasing of cryptotanshinone’s concentrations.CONCLUSION Cryptotanshinone affects the metabolic rate of aspirin esterase,so their interaction should be paid attention when clinical combined use of cryptotanshinone and aspirin.This paper’s research is advantageously used in guiding use of both drugs rationally in clinical trials.
- DOI：
10.13286/j.cnki.chinhosppharmacyj.2014.02.04
- Series：
- Subject：
- Classification Code：
R285.5
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