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Progress in Modern Biomedicine. 2014, (28)

Observation on the Clinical Characteristics and Follow-up of Autosomal Dominant Polycystic Kidney Combined with Intracranial AneurysmsChinese Full Text

XIAO Liao-yuan;SHENG Jun;YU Sheng-qiang;WANG Peng;MEI Chang-lin;Department of Neurology,General Hospital of Lanzhou Military Command;Chang Zheng hospital,second military medical university;

Abstract: Objective: To Iinvestigate the clinical characteristics and prognosis of autosomal dominant polycystic kidney disease（ADPKD） with intracranial aneurysm（ICA）. Methods: Patients who were diagnosed as ADPKD from November 2007 to November 2008 in CHANG ZHENG hospital were selected as research objects. Their clinical data and MRI data were collected and analyzed, and patients with ICA were followed up（recheck MRI and collect clinical data）. Results: 355 patients with ADPKD were found. The incidence rate was 12.4%, which increased as the age increased, reaching a peak value of 23.3% in the 60-69 year age group. The incidence rate of ICA in patients with ADPKD with a positive family history of hemorrhagic stroke was higher than that lack such family history（P＜0.05）. Most aneurysms were small（median diameter 3.85±3.25 mm） and all in the anterior circulation, the most common location was in internal carotid artery（48.1%）.21 patients, 27 aneurysms had imaging follow-up. During cumulative imaging follow-up of43.5±4.3 months, no de novo UIA was detected and two ICA grew obviously with enlargement rate was 7.4%. No evident change was detected in the remaining 25 aneurysms, no aneurysm ruptured. Conclusion: Patients whose age were older than 30 or had family history of hemorrhagic stroke were pretended to suffer from ICA. Most ICAs were small and located in the anterior circulation, during the duration of followed-up, the majority of ICA hadn’t enlarged and ruptured.
Keywords：

ADPKD; ICA; Screening; Follow-Up;

  • DOI：

    10.13241/j.cnki.pmb.2014.28.017

  • Series：

  • Subject：

  • Classification Code：

    R692.1

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