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Progress in Modern Biomedicine. 2014, (27)

Correlation Analysis between Peripheral Blood Mononuclear Cell Numbers and Type 2 Diabetes MellitusChinese Full Text

WEI Hong-xia;SONG Hong-yan;ZHANG Kui;LI Lei;TAN Ting-ting;ZHANG Zheng-fang;QIAN Shi-ning;The Department of Medical Laboratory of Drum Tower Hospital Affiliated to Medical School of Nanjing University;

Abstract: Objective: To improve traditional counting method of peripheral blood mononuclear cells, and investigate association between quantity of peripheral blood mononuclear cell and type 2 diabetes mellitus（DM）. Methods: Mononuclear cells of 30 healthy people were obtained by density gradient centrifugation, mixing with different colored dilution and counting in continuous 5 days,establishing interassay variation and intraassay coefficient of variation;Peripheral blood mononuclear cell of 29 type 2 diabetic patients were gained by above-mentioned method; Plasma lipids were measured by 7600-020 E automatic biochemistry analyzer. Results:Mononuclear cells of healthy people were mixed by staining solutions, there is no statistics significance among counted numbers（P ＞0.05）; Comparing with healthy control, there is no statistics significance between absolute value of Mononuclear cells of type 2 diabetic patients（P＞0.05）, serum TG, TC, LDL were higher obviously, with statistics significance（P＜0.05）, there is difference among results of other index. In control, counted numbers of mononuclear cells were positive correlation with leucocyte（r=0.611,P ＜0.05）, negative correlation with TC, LDL（r1=-0.550, r2=-0.605, P＜0.05）. In type 2 diabetic group, counted numbers of mononuclear cells was only negative correlation with LDL（r=-0.104, P＜0.05）. Conclusion: Numbers of mononuclear cells is no obviously association with type 2diabetic patients.
Keywords：

Numbers of mononuclear cells; Type 2 diabetic mellitus;

  • DOI：

    10.13241/j.cnki.pmb.2014.27.024

  • Series：

  • Subject：

  • Classification Code：

    R587.1

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