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Progress in Modern Biomedicine. 2014, (25)

Clinical Significance of Platelet Parameters, hs CRP and Immunoglobulin Joint Detection in Patients with HepatitisChinese Full Text

SHI Ya-ling;LIU Li-er;YANG Yue-qin;CHEN Wei-hui;LIANG Kai-yan;Department of Clinical Laboratory,the Eighth People’s Hospital of Guangzhou;

Abstract: Objective: To explore and research the clinical significance of platelet parameters, hypersensitive c-reactive protein（hs- CRP） and immune globulin combined detection in patients with hepatitis, and provide a reference for clinical diagnosis and treatment of patients with hepatitis. Methods: A total of 156 patients with various viral hepatitis（48 cases of acute hepatitis, 56 cases of chronic hepatitis, 24 cases of fulminant hepatitis and 28 cases of hepatocirrhosis） were selected, 40 cases of healthy patients undergoing physical examination were chosen as control group. Platelet parameters, platelet count（PLT）, mean platelet volume（MPC）, platelet deposited（PCT）and platelet distribution width（PDW）, hypersensitive c-reactive protein and serum immunoglobulin（IgA, IgG, IgM） level of 5 groups were detected and measured, and the changes in these indicators were analyzed. Results: Except for that there were no significant difference in platelet count（PLT） between severe hepatitis group and liver cirrhosis group, in PCT between chronic of hepatitis group and severe hepatitis group, in PDW among 3 groups of acute hepatitis, liver cirrhosis group and the control group, the difference between any two groups were statistically significant（P＜0.05）; hs-CRP of groups of patients with hepatitis were significantly higher than the control group（P＜0.01）, and the difference in the immunoglobulin level were also statistically significant compared with control group. Conclusion: Platelet parameters, hypersensitive c-reactive protein（hs-CRP） and immunoglobulins levels of patients with hepatitis can indicate hepatitis condition changes, the joint detection of these tree indicators can provide a certain reference for the diagnosis of hepatitis, the choice of treatment and curative effect evaluation.
Keywords：

Hepatitis; Platelet parameters; Hypersensitive c-reactive protein; Immune globulin; Joint detection;

  • DOI：

    10.13241/j.cnki.pmb.2014.25.039

  • Series：

  • Subject：

  • Classification Code：

    R512.62

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