The Differential Diagnostic Value of Interferon-γ, Interleukin-2, Tumor Necrosis Factor α and Adenosine Deaminase in Tuberculous and Malignant Pleural EffusionEnglish Full Text
REN Zhao-qiang;XING Wei-cong;SUN Yong;LIU Fei;LIN Cun-zhi;The Affiliated Hospital of Qingdao University;
Abstract: Objective: To explore the differential diagnostic value of interferon-γ（IFN-γ）, interleukin-2（IL-2）, tumor necrosis factor α（TNF-α）, and adenosine deaminase（ADA） level in the tuberculous and malignant pleural effusions. Methods: A total of eighty-eight specimens of pleural effusion were collected from 88 patients with pleural effusion in respiratorydepartment of affiliated Hospital of Medical College of Qingdao University and Qingdao Thoracic Hospital from September 2012 to March 2013. Among them,46 pleural specimens were diagnosed as malignant, and the others were diagnosed as tuberculous. Enzyme-linked immunosorbent assay（ESISA） was used to detect the concentration of IFN-γ, IL-2, TNF-α and ADA in tuberculous and malignant pleural effusions. Receive operating characteristic curve（ROC） analysis was used to analyze whether there are significant differences between the two groups of patients with pleural effusion in concentration of IFN-γ, IL-2, TNF-α and ADA. Results: Tuberculous pleural effusion group of IFN-γ,IL-2, TNF-α and ADA was significantly higher than that of malignant pleural effusion group, and the difference was statistically significant（ t = 8.118, 8.126, 8.066, 7.221; P＜0.05）; ROC analysis showed that pleural effusion of IFN-γ, IL-2, TNF-α and ADA in the diagnosis of the critical value of 201.45 pg/mL, 41.91 pg/mL, 21.55 pg/mL, 33.78 U/L, the sensitivity and specificity for IFN-γ, IL-2,TNF-α and ADA in pleural fluid were 91.3 %, 93.5 %, 91.2 %, 89.1 % and 91.0 %, 92.1 %, 89.9 %, 90.1 %, respectively.Conclusion:The IFN-γ, IL-2, TNF-α and ADA concentration in tuberculous and malignant pleural fluid are significant for the early diagnosis and differential diagnosis.
- DOI：
10.13241/j.cnki.pmb.2014.23.018
- Series：
- Subject：
- Classification Code：
R521.7;R561.3
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