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Progress in Modern Biomedicine. 2014, (22)

Effects of Dopaminergic Agents on the Sleep Disorders of Parkinson Disease Patients at Early StageChinese Full Text

GAO Juan;YANG Xue-qin;LIU Shun-da;ZHANG Hua;QU Chuan-yong;GAO Yong-ying;QI Ming-shan;Department of Internal Medicine, The Ningxia Hui Autonomous Region people’s Hospital;

Abstract: Objective: To evaluate the relationship between dopaminergic agents and sleep disorders of Parkinson disease（PD）patients at early stage. Methods: Eighty-four consecutive PD patients at early stage（Hoehn-Yahr grade Ⅰ- Ⅱ） and age-matched 87 healthy controls were enrolled in this study. Parkinson disease sleep scale（PDSS） was used to evaluate sleep status. Non-conditional Logistic regression models were used to calculate odds ratios and its corresponding 95% confidence interval（95%CI）. Results: The PDSS score of PD group was significantly lower than that of control group（P=0.000）, but the score of Hamilton depression rating scale（HAMD） of PD group was significantly higher than that of control group（P=0.000）. Agrypnia was found the main type of sleep disorder for PD patients at early stage. Dopaminergic agents（OR=5.50, 95%CI: 1.96-15.81） could increase risk of sleep disturbance, and lower score of HAMD（OR=0.35, 95%CI: 0.13-0.93） could decrease risk of sleep disorders among PD patients. Conclusion: Different types of sleep disorder could be found in PD patients at early stage. Dopaminergic agents and depression may make the situation of sleep disorders worse for PD patients at early stage. Intervention and treatment measures should be introduced to prevent development of sleep disorders among PD patients at early stage.
Keywords：

Parkinson disease; Sleep disorders; Dopaminergic agents; Depression;

  • DOI：

    10.13241/j.cnki.pmb.2014.22.027

  • Series：

  • Subject：

  • Classification Code：

    R742.5

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