Vascular Occlusion of the Clinical Value of Ischemic Preconditioning in Liver Cancer ResectionChinese Full Text
CHEN Pei-sheng;LUO Han-chuan;QIN Jun-shi;WU Rui-zheng;HE Xin-xin;Department of Hepatobiliary Surgery,Eighth Affiliated Hospital of Guangxi Medical University;
Abstract: Objective: To investigate the blood flow blocked the clinical value of ischemic preconditioning in liver cancer resection.Methods: 96 patients with primary liver cancer and the use of partial liver resection for treatment of patients, the patients were randomly divided into observation group and control group, with 48 cases in each group, in the observation group, partial resection of hepatic hilar previously blocked blood flow were given a 5min ischemia and reperfusion treatment. Control group received no intervention. Preoperative and postoperative 1 day, 3 days, 7 days, respectively biochemical tests and 1h before surgery and on postoperative Fas-mRNA expression, Caspasc-3 activity and AI were measured, observed and recorded postoperative complications in patients, operative time,blood loss and hospital stay. Results: After 1 day, 3 days, 7 days, the content of AST, ALT, TBIL in the observa- tion group were significantly better than the control group（P＜0.05）; After 1 day,two groups of patients had significantly lower ALB, the control group was lower than in the observation group（P＜0.05）. Postoperative hospital stay in the observation group was 13.28 ±3.85 days, the control group was 19.48 ± 4.92 days, the observation group was significantly lower than the control group（P＜0.05）; after 1h, Fas-mRNA expression,Caspasc-3 activity in two groups of patients were significantly improved compared to before the blockade, but in- crease rate in the observation group was significantly lower than the control group, the difference was statistically significant（P＜0.05）; Before blocking,the two groups showed no liver cell apoptosis, 1h after surgery, the two groups were seen liver cell apoptosis, and significantly higher in the control group was significantly higher than in the observation group（P＜0.05）. Conclusion: Ischemic preconditioning techniques blocking blood flow is simple, side effects of important features used in liver cancer resection has significant advantages in terms of protection of liver function.
Keywords：
Vascular occlusion of ischemic preconditioning techniques; Primary liver cancer; Liver resection surgery;
- DOI：
10.13241/j.cnki.pmb.2014.21.022
- Series：
- Subject：
- Classification Code：
R735.7
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