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Progress in Modern Biomedicine. 2014, (21)

Cytotoxicity of Cadmium Telluride Quantum Dot on PC-12 CellsChinese Full Text

BAO Yi-ling;LI Yi-bai;FAN Jia;GE Ya-kun;College of Life Information Science and Instrument Engineering,Hangzhou Dianzi University;

Abstract: Objective: To investigate the biological security of CdTe QDs. Methods: CdTe QDs which was made by hydrothermal method and covered by MSA was chosen as the object. The cells were divided into control group and CdTe QDs-treated groups with different concentrations of CdTe QDs. Affected by CdTe QDs. The cell morphology and the fluorescence of CdTe QDs was observed by inverted fluorescence microscope. The cell survival rate was examined by alamarBlue, and cell apoptotic morphology in staining was detected by Hoechst 33342. The influence of CdTe QDs on the apoptosis of PC-12 was examined by Annexin V-FITC single-stain procedure.Results: Affected by CdTe QDs, cells in the experimental group treated with low concentration of CdTe QDs changed not obviously while the morphology of those treated with high concentration obviously changed. In addition, they swelled and became round, the number of which decreased, and the survival rate decreased significantly. It was obvious apoptosis in staining. Conclusions: We consider that quantum point contact with cells, will be uptaken into the cell, together in various organelle, damage the function of the organelle, cause various pathways of apoptosis mechanism and cause cell death at last.
Keywords：

Cadmium telluride; Quantum dots; PC-12; Cell viability; Apoptosis;

  • DOI：

    10.13241/j.cnki.pmb.2014.21.012

  • Series：

  • Subject：

  • Classification Code：

    R114

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