Advances in Clinical Application of Recombinant Human Brain Natriuretic PeptideChinese Full Text
ZHANG Xue-yan;LI Xue-qi;LI Jing-xiu;YAN Shu-jun;The Fourth Affiliated Hospital of Harbin Medical University;
Abstract: In recent years, with the further research of pathological physiological and molecular mechanism about heart failure and pulmonary hypertension, the pharmacotherapy on these diseases have a great advance. The human brain natriuretic peptide（BNP）, as the only natural renin-angiotensin-aldosterone antagonist in the diagnosis and treatment of heart failure, caused wide public concern.Therefore, exogenous BNP become one hot research spot in heart failure treatment. Recombinant human brain natriuretic peptide（rhBNP） is a kind of synthetic endogenous hormone. It has the functions of vasodilation, diuresis, reducing the preload and afterload of cardiac, inhibiting the renin-angiotensin-aldosterone system and sympathetic nervous system, and can effectively improve the hemodynamic of congestive heart failure patients.Recent research shows that rhBNP have remarkable effection in the treatment of cardiovascular diseases, so this article is aimed to review the clinical application of rhBNP.
Keywords：
Recombinant human brain natriuretic peptide; Heart failure; Pulmonary hypertension; Clinical application;
- DOI：
10.13241/j.cnki.pmb.2014.20.046
- Series：
- Subject：
- Classification Code：
R541.6
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