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Progress in Modern Biomedicine. 2014, (16)

Effects and Mechanisms of Sodium Ferulate on Human Aortic Soomth Muscle Cells and Endothelial CellsChinese Full Text

ZHU Xiao-fei;LI Jiang;WANG Bao;LI Yu-qian;ZHAO Zhen-wei;Department of Neurology, Kunming General Hospital of PLA;Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University;

Abstract: Objective: To study the effects and mechanisms of Sodium ferulate（SF） on human aortic soomth muscle cells（HASMCs） and endothelial cells（HAECs） to approach its potential possibility for in-stent restenosis. Methods: HASMCs and HAECs were treated with different concentrations of SF and divided into 6 groups（0 μg/ml, 0.1 μg/ml, 1 μg/ml, 10 μg/ml, 100 μg/ml, and 1000 μg/ml）.Cell viability was determined by CCK-8 kit. Cell migration distance was evaluated by Scratch wound healing assay. Changes of FoxM1 and VEGF expression in HAECs were detected through the Immunocytochemistry method, Western blot and image analysis. Results: SF inhibited proliferation and migration of HASMCs in a does-dependent manner（10-1000 μg/ml）（P＜0.05）. However, SF promoted proliferation and migration of HAECs in a dose-dependent manner（0.1-100 μg/ml）（P＜0.05）. The expression of FoxM1 and VEGF was increased in a does-dependent manner in HAECs（P ＜0.05）. Conclusion:SF may inhibit proliferation of HASMCs, and promote vascular endothelial healing through increasing the expression of FoxM1 and VEGF. It suggests that SF may be an effective agent for in-stent restenosis.
Keywords：

HASMCs; HAECs; In-stent restenosis;

  • DOI：

    10.13241/j.cnki.pmb.2014.16.012

  • Series：

  • Subject：

  • Classification Code：

    R965

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