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Progress in Modern Biomedicine. 2014, (13)

Clinical Analysis of 23 children with Hodgkin LymphomaEnglish Full Text

WANG Meng-meng;LI Xue-rong;JIANG Jian;ZHONG Ren;LU Yuan;SONG Ai-qin;SUN Li-rong;Department of pediatric Hematology, the Affiliated Hospital of Qingdao University;

Abstract: Objective: To investigate the pathological characteristic, clinical features and prognosis in children and adolescent with Hodgkin’s lymphoma. Methods: 23 patients of childhood and adolescent with Hodgkin’s lymphoma were treated in department of pediatric Hematology of the affiliated Hospital of Qingdao university from 2001 to 2013. The clinicopathological and follow-up data of the patients were retrospectively reviewed. The clinical rate in the difference of groups was analyzed by x2test and fisher exact test. Results: 23 cases were diagnosed in the study. The mean age was 7.5 years. The sex-ratio was 6.7:1. Stage I, II, III and IV were accounted for 13.0%, 26.2%, 30.4%, 30.4% respectively. There was 1 patient of NLPHL（4.3%）, 10 patients of MC（43.5%）, 11 patients of LP（47.9%） and 1 patient of NS（4.3%）. The involved parts were mostly the cervical lymph node, followed by mediastinum, enterocoelia, retroperitoneal, spleen, skeleton and lung tissue, of which there were 2 patients with huge mediastinum mass. 8 patients had B symptoms（34.7%） at diagnosis. After 2 cycles of initial chemotherapy, the overall response rate（ORR） reached 100%. And complete response（CR） rate was 69.6% while partial response（PR） rate was 30.4%. The CR rate of patients at stage I and II（100%） was significantly higher than that at stage III and IV（50%）, P＜0.05. 7 of 23 patients were relapsed. The recurrence rate of stage III and IV was higher than that at stage I and II（46.2% verse 11.1%,P=0.0098）. For the recurrence rate of patients, there was significantly statistical difference between patients with B symptoms and those without B symptoms（P=0.019）. 2 patients with mediastinal neoplasm were relapsed. There was no statistical difference between the relapse of disease and each histological subtype（x2=2.695, P＞0.05）. Conclusions: The prognosis of children and adolescent with Hodgkin’s lymphoma is better, but the patients of stage III and IV or ones with B symptom and huge mediastinal lump have higher recurrence rate. The hierarchical therapy is adopted for children with HL in order to reach the long-term survival.
Keywords：

Hodgkin lymphoma; Children; Clinical feature; Prognosis; Relapse;

  • DOI：

    10.13241/j.cnki.pmb.2014.13.032

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  • Classification Code：

    R733.1

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