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Progress in Modern Biomedicine. 2014, (06)

Effects of Somatostatin Combined with Omeprazole on the Treatment of Severe Acute PancreatitisChinese Full Text

WANG Qi;GUO Xiao-dong;MENG Fan-ping;LI Rui-sheng;ZHANG Hong-ping;92301 Troops of PLA;302 Hospital of PLA;

Abstract: Objective: To explore the clinical effects of somatostatin combined with omeprazole on the treatment of severe acute pancreatitis. Methods: 98 patients with severe acute pancreatitis who were treated in our hospital from October 2005 to 2012 were selected in our study and randomly divided into the observation group and the control group with 49 cases in each group. The patients in the control group were treated by the conventional method, while the patients in the observation group were treated by somatostatin combined with omeprazole besides the conventional treatment. The course of the treatment was seven days. Then the clinical effect, recovery time and incidence of complications of patients were compared and analyzed between two groups. Results: The treatment efficacy of patients in the observation group was 93.9% which was significantly higher than that of the patients in the control group 71.4%（P＜0.05）. The average hospitalization, intestinal recovery, abdominal pain remission, AMY, UAMY and other indexes restored to normal time and the prognosis of patients were significantly better than those of the patients in the control group, and there were statistically significant differences between two groups（P＜0.05）. Conclusion: It is suggested that Elderly patients with severe pancreatitis treated by somatostatin combined with omeprazole could be well promoted with the advantages of high effective rate, significant improvement of symptoms, shorter time for treatment, less incidence of complications and lower death.
Keywords：

SAP; Somatostatin; Clinical efficacy; Omeprazole;

  • DOI：

    10.13241/j.cnki.pmb.2014.06.025

  • Series：

  • Subject：

  • Classification Code：

    R657.51

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