Synthesis and Characterization of Phosphonium Modified ChitosanChinese Full Text
QIAN Chang-yun;XU Xiao-fen;GUO Ai-jie;GUO Sheng-rong;School of Pharmacy, Shanghai Jiao Tong University;
Abstract: Objective: To improve the water solubility and enlarge the application of chitosan. Methods: Phosphonium chitosan（NPCS） was synthesized under the homogenous reaction system with HOBt and EDC as the catalyst and the chemical structure and crystallization of NPCS was characterized by 1H-NMR, FT-IR and XRD. Water solubility and pH stability of NPCS were investigated. Results: NPCS with two degrees of substitution（12.1 % and 21.5 %） were successfully synthesized and compared with chitosan, NPCS had low crystallization, better water solubility and pH stability. Conclusion: Phosphonium modified chitosan had favorable water solubility and good application prospect in drug delivery system and antibacterial materials.
Keywords：
- DOI：
10.13241/j.cnki.pmb.2014.03.009
- Series：
- Subject：
- Classification Code：
R914
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