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Progress in Modern Biomedicine. 2014, (02)

The Preparation and Properties of Poly（vinyl Alcohol）-Dex-CMC Hydrogel PatchChinese Full Text

FENG Yan;WU Zao-zhan;CHEN Li-zu;XU Jian-xiong;GUO Qiu-yuan;HUANG Xi-wen;YUAN Wei-en;Pharmacy college of Shanghai Jiao Tong University;

Abstract: Objective: Investigation the preparation of PVA/glucan/sodium carboxymethyl cellulose composite hydrogel for external use, and comparing with pure PVA hydrogel in physical properties and drug system in vitro release. Methods: Make use of freeze- thaw physical crosslinking methods preparation hydrogel loading insulin model drug requests for external use, through the universal tensile machine and differential scanning calorimetry study the requests of physical properties, the use of HPLC on the requests of the in vitro release behavior. Result: PVA composite hydrogel for external use paster compared with pure PVA hydrogel paster toughness decrease, rigid increase, the in vitro release better. Conclusion: Through the amalgamation of material friendly PVA and polysaccharide glucan、sodium carboxymethyl, the insulin composite hydrogel paster has not only good physical properties, but also good release behavior and is better than the performance of the current pure PVA hydrogel paster which current literature reports, and is expected to continue to study optimization performance.
Keywords：

Poly（vinyl alcohol） hydrogel; Insulin; Dextran; Carboxymethylcellulose sodium; Physical property; Vitro release;

  • DOI：

    10.13241/j.cnki.pmb.2014.02.011

  • Series：

  • Subject：

  • Classification Code：

    R318.08

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