The Mechanism of Up-Regulation of CGRP on MrgC in Cultured Dorsal Root Ganglia of RatsChinese Full Text
WANG Dong-mei;DAI Fei-hong;HONG Yan-guo;ZHOU Xiao-long;RUAN Li-qin;College of Life Sciences and Provincial Key Laboratory of Developmental Biology and Neuroscience, Fujian Normal University;
Abstract: Objective: To investigate the effect of chronic BAM8-22 treatment on the expression of calmodulin gene related with peptide（ CGRP） in cultured sensory ganglion. Methods: DRG and TG tissue of rats were cultured in vitro after BAM8-22 and L-NAME treatment. The changes of CGRP content was detected by enzyme linked immunosorbent assay. Results: Compared with the control group, the expression of CGRP increased after the consecutive treatment of selective SNSR agonist（BAM8-22） for 4 days. Combined that treated with L-NAME（a non-selective nitricoxide synthesis inhibitor）, the expression of CGRP was up-regulated differently with different doses of L-NAME. Conclusion: Chronic activation of SNSR resulted in the enhanced expression of CGRP, it may be the cellular mechanism for reducing the analgesic effect of morphine after continuous activation of SNSR.
Keywords：
MrgC receptor（Sensory neuron-specific receptors）; Dorsal root ganglin; Calcitonin gene-related peptide; Nitric oxide synthase;
- DOI：
10.13241/j.cnki.pmb.2014.02.004
- Series：
- Subject：
- Classification Code：
R392
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