Evaluation of SphK1 protein expression and its clinical significance in gastric cancer tissuesChinese Full Text
YANG Jin;WANG Wei;Pathology Department,People’s Hospital of Mianyang City;
Abstract: Objective:To explore the expression of SphK1 and its clinical significance in gastric cancer tissues.Methods:A total of 58 samples of surgically resected gastric cancer and matched normal tumor-adjacent tissues were subjected to immunohistochemistry for SphK1 protein detection.Correlation between SphK1 protein expression and different clinicopathological features in gastric cancer was analyzed.Results:Positive expression rate of SphK1 protein was 79.3%（46/58）in gastric cancer tissues and was 24.1%（14/58）in matched normal-adjacent tissues,the difference was significantly（χ2=35.352,P=0.000）.The expression of SphK1 protein was significantly correlated with depth of infiltration（χ2=4.312;P=0.038）,occurrence of lymph node metastasis（χ2=7.459;P=0.006）and TNM tumor stage（χ2=4.156;P=0.041）.Conclusion:The expression of SphK1 is elevated and its high-expression is associated with poor clinicopathological parameters in gastric cancer tissues,suggesting SphK1 may promote tumour progression in gastric cancer.
- DOI：
10.13210/j.cnki.jhmu.20140430.013
- Series：
- Subject：
- Classification Code：
R735.2
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