自身免疫性皮肤病,可溶性共刺激分子,共刺激分子," /> 自身免疫性皮肤病,可溶性共刺激分子,共刺激分子,"/> autoimmune cutaneous disease, soluble costimulatory molecules, costimulatory molecules,"/> <span style="font-size:12px;">可溶性共刺激分子在自身免疫性皮肤病中的研究进展</span>

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (1): 71-76.doi: 10.12144/zgmfskin202401071

• 综述 • 上一篇    

可溶性共刺激分子在自身免疫性皮肤病中的研究进展

陈璐1,张晓艳1,胡颖2,姚昱旭1,季江1,焦晴晴2   

  1. 1苏州大学附属第二医院皮肤性病科，苏州，215004；2苏州大学附属第一医院皮肤性病科，苏州，215006
  • 出版日期:2024-01-15 发布日期:2023-12-25

Update of soluble costimulatory molecules in autoimmune cutaneous disease

CHEN Lu1, ZHANG Xiaoyan1, HU Ying2, YAO Yuxu1, JI Jiang1, JIAO Qingqing2   

  1. 1 Department of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; 2 Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
  • Online:2024-01-15 Published:2023-12-25

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摘要： 可溶性共刺激分子（soluble costimulatory molecules）是共刺激分子的可溶性形式，参与共刺激信号的传递并发挥重要的自我调控作用，其异常表达会影响机体免疫应答和免疫耐受的建立，与自身免疫性皮肤病的免疫调控和发生发展密切相关。本文就可溶性共刺激分子在自身免疫性皮肤病中的研究进展进行综述，旨在为临床医师和科研工作者明确该病的发病机制及有效治疗方案提供参考。

关键词: 自身免疫性皮肤病')">">自身免疫性皮肤病, 可溶性共刺激分子, 共刺激分子

Abstract: Soluble costimulatory molecules are soluble forms of costimulatory molecules, which participate in the transmission of costimulatory signals and play an important role in self-regulation. Their abnormal expression will affect the body's immune response and the establishment of immune tolerance. It is closely related to the immune regulation, occurrence and development of autoimmune skin diseases. The update of soluble costimulatory molecules in autoimmune cutaneous disease was reviewed in this paper, in order to provide a reference for clinicians and researchers to clarify the pathogenesis and effective treatment of this disease.

Key words: autoimmune cutaneous disease')">">autoimmune cutaneous disease, soluble costimulatory molecules, costimulatory molecules