中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (1): 50-52.doi: 10.12144/zgmfskin202401050

• 病例报告 • 上一篇    下一篇

托法替布治疗顽固性SAPHO综合征一例

赛雯雯1，2,王广进1，2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2024-01-15 发布日期:2023-12-25

Refractory SAPHO syndrome treated with tofacitinib: a case report

SAI Wenwen1，2, WANG Guangjin1，2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2024-01-15 Published:2023-12-25

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摘要： 报道一例应用传统药物甲氨蝶呤、阿维A胶囊等药物治疗仍无法控制病情的顽固性SAPHO综合征患者，应用阿达木单抗维持治疗6周、依奇珠单抗维持治疗6周后病情仍无法控制，最终调整用药为JAK抑制剂托法替布治疗75天后皮疹完全消退，指趾甲近端见光滑新甲，胸锁关节无压痛。

关键词: 托法替布, 顽固性SAPHO综合征, JAK抑制剂

Abstract: We report a case of refractory SAPHO syndrome in which the disease could not be controlled by traditional drugs such as methotrexate and aveloxan capsules. After 6 weeks of maintenance treatment with adalimumab and echizumab, the disease remained uncontrolled.The rash completely disappeared,smooth new nail proximal to the toenail, no pressure pain in the sternoclavicular joint,after 75 days of treatment with the JAK inhibitor tofacitab.

Key words: tofacitinib, refractory SAPHO syndrome, Janus kinase inhibitor