血吸虫及其衍生物调节免疫失调性疾病的研究进展

doi:10.12140/j.issn.1000-7423.2023.01.013

中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (1): 85-91.doi: 10.12140/j.issn.1000-7423.2023.01.013

血吸虫及其衍生物调节免疫失调性疾病的研究进展

栗根¹(), 孙同骏¹, 钱亚云, 李倩倩¹, 杨小迪^*()

1.安徽省感染与免疫重点实验室，安徽蚌埠 233030
2.蚌埠医学院第一附属医院儿科，安徽蚌埠 233030
3.蚌埠医学院病原生物学教研室，安徽蚌埠 233030

收稿日期:2022-05-17 修回日期:2022-09-06 出版日期:2023-02-28 发布日期:2023-01-17
通讯作者: * 杨小迪（1980-），男，博士，教授，从事寄生虫感染与免疫研究。E-mail：yxd_qf@163.com
作者简介:栗根（2001-），男，本科在读，从事寄生虫感染与免疫研究。E-mail：ligen20010915@163.com
基金资助:
安徽省自然科学基金(2008085MH260);蚌埠医学院“512 人才培育计划”(by51201205);蚌埠医学院研究生科研创新计划(Byycx21087);国家级大学生创新训练项目(202010367006)

Research progress on the role of schistosome and its derivatives on modulation of immune dysregulatory diseases

LI Gen¹(), SUN Tongjun¹, QIAN Yayun, LI Qianqian¹, YANG Xiaodi^*()

1. Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu 233030, Anhui, China
2. Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233030, Anhui, China
3. Department of Microbiology and Parasitology, Bengbu Medical College, Bengbu 233030, Anhui, China

Received:2022-05-17 Revised:2022-09-06 Online:2023-02-28 Published:2023-01-17
Contact: * E-mail: yxd_qf@163.com
Supported by:
Science Foundation of Anhui Province(2008085MH260);512 Talents Development Project of Bengbu Medical College(by51201205);Postgraduate Scientific Research Innovation Program of Bengbu Medical College(Byycx21087);Innovation and Entrepreneurship Training Program for College Students(202010367006)

摘要/Abstract

摘要：

血吸虫是一种人及哺乳动物体内寄生的蠕虫，在与宿主共进化过程中，通过调控宿主固有及适应性免疫应答以诱导其免疫逃逸，营造有利于其长久寄生的微环境。近年来，血吸虫及其虫源性成分对过敏性、自身免疫性和代谢性疾病等多种免疫失调性疾病的药理效应成为研究热点。本文综述了血吸虫及其衍生物在各种免疫失调性疾病中的调节作用和相关机制，以期为临床治疗提供实验基础和理论依据。

关键词: 血吸虫, 衍生物, 免疫调节, 免疫失调性疾病

Abstract:

Schistosoma sp. is a parasite infect in mammals including humans. During co-evolution of host and schistosomes, the parasite have developed mechanisms that manipulate the host innate and adaptive immunity to create a microenviroments that benefi its survival. Recently, the pharmacological effects of schistosome infection and relevant molecules in the management of allergy, autoimmune and metabolic diseases has attracted great attention. This article reviews the modulatory role and underlying mechanisms of schistosomes and their derivatives in immune dysregulatory diseases, to provide a basis for subsequent laboratory and clinical investigations.

Key words: Schistosome, Derivatives, Immunoregulation, Immune dysregulatory diseases

中图分类号:

R383.24

栗根, 孙同骏, 钱亚云, 李倩倩, 杨小迪. 血吸虫及其衍生物调节免疫失调性疾病的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 85-91.

LI Gen, SUN Tongjun, QIAN Yayun, LI Qianqian, YANG Xiaodi. Research progress on the role of schistosome and its derivatives on modulation of immune dysregulatory diseases[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(1): 85-91.

图/表 1

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血吸虫及其衍生物调节免疫失调性疾病的研究进展

Research progress on the role of schistosome and its derivatives on modulation of immune dysregulatory diseases

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