To analyze the constituents of upper urinary tract stones among adults in different geographic regions of Hebei, providing evidence for clinical treatment and prevention of upper urinary tract stones.

Outpatients and inpatients (n=1 192, ≥18 years old) with upper urinary calculis who were from three geographical regions (mountainous, plain and coastal) of Hebei were selected from the Second Hospital of Hebei Medical University in 2019. Upper urinary tract stones of the outpatients removed by extracorporeal shock wave lithotripsy, and those of the inpatients removed by surgery were collected for quantitative and qualitative constituent analyses by geographical region using infrared spectrometry.

Upper urinary tract stones were more often found in those 30 to 70 years old, with a male to female ratio about 1.75∶1. Kidney stones and ureteral stones accounted for similar proportions (about 1.1∶1) , and the mixed stones were more common (61.5%) . Calcium-containing stones were the major type of upper urinary tract stones in participants from each geographic regions, with calcium oxalate monohydrate being the most. The prevalence of infectious stones showed no significant differences across participants from three regions (P>0.05) . The prevalence of uric acid-containing stones in participants from plain was significantly different from that of participants from mountainous or coastal region (P<0.05) .

Calcium-containing stones were the most common prevalent in upper urinary tract stones patients across three geographic regions of Hebei, and the prevalence of uric acid-containing stones in those from mountainous or coastal region was higher, which require the attention of urologists.