关键词: 幽门螺杆菌, 代谢综合征X, 脂肪肝, 血糖, 血压

Abstract: Objective　To analysis the effects of H.pylori infection on metabolic indicators in elderly and young/middle-age people.Methods　A retrospective study was conducted，based on the clinical data from 1 828 subjects found to be healthy during physical examinations in the General Hospital of the PLA Rocket Force between May 2017 and June 2017.According to the presence of H.pylori infection，the subjects were divided into an H.pylori-positive group and an H.pylori-negative group.The subjects were further divided into an elderly H.pylori-positive subgroup，an elderly H.pylori-negative subgroup，a young/middle-age H.pylori-positive subgroup，and a young/middle-age H.pylori-negative subgroup，with 60 years of age as the cutoff.The data from physical examinations，including systolic blood pressure，diastolic blood pressure，fasting blood glucose，postprandial blood glucose，alanine aminotransferase，total cholesterol，triacylglycerol，high-density lipoprotein cholesterol，low-density lipoprotein cholesterol，13C breath test and abdominal ultrasound，were collected and analyzed.Results　The level of systolic blood pressure，diastolic blood pressure and postprandial blood glucose，and the rates of systolic blood pressure，diastolic blood pressure and fasting blood glucose in the H.pylori-positive group（n=580） were higher than those in the H.pylori-negative group（n=1 248）（P<0.05）.The rates of abnormal diastolic blood pressure and fasting blood glucose in the elderly H.pylori-positive subgroup（n=143） were higher than the elderly H.pylori-negative subgroup（n=287）（P<0.05）.Systolic blood pressure，diastolic blood pressure，postprandial blood glucose，alanine aminotransferase and triacylglycerol were higher，and high-density lipoprotein cholesterol was lower，in the young/middle-age H.pylori-positive subgroup（n=437） than the young/middle-age H.pylori-negative subgroup（n=961）（P<0.05）.The rates of abnormal systolic blood pressure，diastolic blood pressure，fasting blood glucose and triacylglycerol，the incidence of nonalcoholic fatty liver disease in the young/middle-age H.pylori-positive subgroup were higher than the young/middle-age H.pylori-negative subgroup（P<0.05）.Conclusion　H.pylori infection may affect body metabolism，and the infection has a greater effect on the metabolism of young and middle-age people than elderly people.Eradication of H.pylori should be pursued among young and middle-age infected patients，and elderly patients should be treated individually.

Key words: Helicobacter pylori, Metabolic syndrome X, Fatty liver, Blood glucose, Blood pressure