李佳帅，刘树佳，胡伟

引用本文： 李佳帅，刘树佳，胡伟.造血干细胞移植病人疲乏现状及影响因素[J].护理研究,2024,38(1):67-74

摘要： 目的： 调查造血干细胞移植（HSCT）病人疲乏现况并分析其影响因素，为制定HSCT病人疲乏的针对性干预措施提供参考。 方法： 选取2019年9月—2020年3月北京市9所三级甲等医院血液科住院部或门诊规律随访治疗的217例HSCT病人为研究对象，采用自设的一般资料调查表、修订版Piper疲乏量表、医院焦虑抑郁量表、国际体力活动问卷简表、锻炼自我效能量表、社会支持评定量表进行调查。 结果： 217例HSCT病人中，131例（60.37%）病人不存在疲乏，27例（12.44%）病人轻度疲乏，49例（22.58%）病人中度疲乏，10例（4.61%）病人重度疲乏。有序Logistic回归分析显示，焦虑、体力活动强度、锻炼自我效能和移植次数是HSCT病人疲乏的影响因素（<0.05）。 结论： HSCT病人疲乏虽有所改善但仍不容乐观，建议根据影响因素针对性实施各项措施，降低病人疲乏水平，提高其生活质量。

关键词： 造血干细胞移植;疲乏;焦虑;抑郁;体力活动;锻炼自我效能;社会支持;影响因素

LI Jiashuai，LIU Shujia，HU Wei

Abstract Objective： To investigate the status quo of fatigue in patients with hematopoietic stem cell transplantation （HSCT） and analyze its influencing factors， so as to provide references for formulating targeted intervention measures for fatigue in patients with HSCT. Methods： 217 HSCT patients who were followed up in the inpatient department or outpatient department of 9 tertiary grade A hospitals in Beijing from September 2019 to March 2020 were investigated with Self⁃Designed General Data Questionnaire， Revised Piper Fatigue Scale， Hospital Anxiety and Depression Scale， International Physical Activity Questionnaire， Exercise Self⁃Efficacy Scale and Social Support Rating Scale. Results： Among 217 HSCT patients，131 patients （60.37%） had no fatigue， 27 patients （12.44%） had mild fatigue， 49 patients （22.58%） had moderate fatigue， and 10 patients （4.61%） had severe fatigue. Ordered Logistic regression analysis showed that anxiety， physical activity intensity， exercise self⁃efficacy and transplant times were the influencing factors of fatigue in HSCT patients （<0.05）. Conclusion： Although the fatigue of HSCT patients has been improved， it is still not optimistic. It is suggested that various measures should be implemented according to the influencing factors to reduce the fatigue level of patients and improve their quality of life.

Keywords hematopoietic stem cell transplantation， HSCT;fatigue;anxiety;depression;physical activity;exercise self⁃efficacy;social support;influencing factors

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