Abstract: The initial rock stress field of the gently inclined ore bed under the valley terrain is greatly affected by the terrain, and the geostress environment of the mining sites in the same mining area and even the panel is quite different. It is important to adopt the structural parameters of the mining site matching with this special geostress environment for the efficient mining of the mining area. Based on the engineering background of Shaiqihe Mining Area in Yichang, this paper puts forward a plan of non-uniform strip mining, calculates the strip mining width by using the simple beam theory and the elastic-plastic theory, and uses FLAC^3D software to simulate the stope with uniform strip mining and non-uniform strip mining respectively, and analyzes the characteristics of stope stability from the aspects of stress, displacement change and plastic zone distribution law. The research results show that compared with the uniform strip mining scheme with all stope structural parameters calculated according to the maximum burial depth of the ore body, the non-uniform strip mining scheme with different burial depth and different mining width makes the stress distribution in the stope more uniform, and improves the production capacity on the premise of ensuring the stability of the stope, which has certain reference significance for the optimization of stope structural parameters under the valley terrain.