To determine the effects of Water retaining Agent(B)application combined with irrigation(W)on yield of winter wheat and water use efficiency under different moisture conditions,two Water retaining Agent levels combined with four irrigation levels were randomly designed in fully balanced blocks.The result showed that under the irrigation levels rate from 20%～80%,the yield increased significantly with the increasing of irrigation level when Water retaining Agent wasnt applied.When Water retaining Agent was applied,the yield reached the highest at the irrigation level of 60%.Soil water content was increased with the increase of irrigation levels or the application of Water retaining Agent.In the booting stage of winter wheat,when the irrigation amount was 60% of field capacity,the soil water content could be increased by 1.57 times when applied Water retaining Agent.The effect of Water retaining Agent on water production efficiency,irrigation utilization efficiency and rainfall utilization efficiency significantly would be decreased in both low irrigation levels and high irrigation levels.Thus,there were close relationships among the effects of irrigation on the yield and water use efficiency,irrigation efficiency,precipitation use efficiency.The highest yield was achieved at 60% of the field moisture capacity irrigation combined with the application of Water retaining Agent under this experiment conditions.