The effects of water and nitrogen coupling on nutrient absorption and water and fertilizer utilization of sand-cultured cucumbers were explored in order to obtain the most suitable water-nitrogen coupling scheme and provide a theoretical basis for scientific management of water and nitrogen in greenhouse sand-cultured cucumbers.With the “Yosemite” fruit cucumber as the test variety，a field experiment of water-nitrogen coupling of sand cultured cucumber was carried out by using the twice-saturated D-optimal design.There were 7 treatments in total，and each treatment was repeated 3 times.The absorption of nitrogen，phosphorus and potassium in various organs of cucumber plants was measured at the seedling stage，flowering stage，early melon stage，full melon stage and last melon stage，and the yield of each treatment was estimated.The result showed that plants at the seedling stage absorbed less nitrogen，phosphorus，and potassium，and the plant nutrient absorption increased rapidly after entering the flowering stage.The nutrient distribution of various organs generally showed that the leaves and fruits absorbed a large amount of nitrogen，while stems，roots and flowers absorbed less nitrogen.The plant’s absorption of nitrogen，phosphorus，and potassium increased with the increase of irrigation level and fertilization，but too high irrigation level and nitrogen application inhibited the plant’s absorption of nitrogen，phosphorus，and potassium.The trend of yield increasing with the increase of irrigation level showed a downward parabolic trend，but the level of irrigation had no significant effect on yield.Yield increased significantly with the increase of nitrogen application rate，but excessive nitrogen application would reduce yield，which conformed to the law of diminishing returns.There is a significantly positive correlation between nitrogen application rate and water use efficiency，and a negative correlation with irrigation level，but it didn’t reach a significant level.The treatment T3 with low water and high nitrogen obtained the highest water use efficiency.Nitrogen application is the main factor affecting fertilizer utilization and utilization efficiency and with the increase of irrigation level，it generally presents a downward parabolic trend.Increased application of nitrogen fertilizer under moderate irrigation level can achieve higher fertilizer utilization and utilization efficiency.Using the entropy TOPSIS method for comprehensive evaluation，the sorting order of the proximity Ci of each treatment was T4>T5>T3>T6>T7>T1>T2，and the optimal water-nitrogen coupling scheme was obtained at treatment T4，which was 80.20% irrigation with 623 kg/hm² of nitrogen fertilizer application.This treatment can achieve the ultimate goal of low input and high output in agricultural production，reduce water and fertilizer waste，and provide a theoretical basis for scientific management of water and nitrogen of cucumber in greenhouse.