| 陈 琼,李变云,刘曙正,等.胃癌内镜筛查对统计治愈比例的影响[J].中国肿瘤,2023,32(1):27-32. |
| 胃癌内镜筛查对统计治愈比例的影响 |
| Influence of Endoscopic Screening on Gastric Cancer Cure Fraction |
| 投稿时间：2022-06-07 |
| DOI：10.11735/j.issn.1004-0242.2023.01.A005 |
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| 中文关键词: 胃癌 内镜筛查 统计治愈 治愈比例 |
| 英文关键词:gastric cancer endoscopic screening statistical cure cure fraction |
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| 中文摘要: |
| 摘 要：［目的］ 评估胃癌统计治愈比例现状及其与胃癌内镜筛查之间的关系。［方法］ 提取2005—2012年林州市以人群为基础的肿瘤登记数据库中ICD-10为C16.0~C16.9范围的胃癌病例数据(共6 172例)，通过链接胃癌人群筛查数据库与肿瘤登记数据库以获取患者是否参加筛查信息，利用混合统计治愈模型建模并估计统计治愈比例及相对生存率，计算比值比（OR）值以及95%可信区间（CI）以评估胃癌内镜筛查和统计治愈之间的关系。［结果］ 曾参加内镜筛查和从未参加内镜筛查胃癌患者的统计治愈比例分别为75.51%(95%CI：69.18%~81.85%)和31.69% (95%CI：30.30%~33.07%)，估计治愈比例两者差值为38.76% (32.35%~45.00%)。参加内镜筛查患者与未参加筛查患者相比，受益于统计治愈的OR为5.84 (95%CI：4.10~8.31)，参加内镜筛查患者受益于贲门胃统计治愈（OR= 6.10，95%CI：3.96~9.39）要高于非贲门胃(OR=5.34，95%CI：2.54~11.23)。［结论］ 参加胃癌内窥镜筛查可以提高胃癌患者统计治愈比例。 |
| 英文摘要: |
| Abstract： ［Purpose］ To evaluate endoscopic gastric cancer screening and its relationship with gastric cancer cure fraction in the population. ［Methods］ A total of 6 172 patients with gastric cancer（ICD-10 code： C16.0~C16.9） diagnosed during 2005—2012 were extracted from Linzhou population-based cancer registration database. The participation in the screening program was acquired by investigating the screening database. The mixture cure model was used to estimate cure fraction and relative survival. The odds ratio（OR） and 95% confidence interval（CI） were calculated to evaluate the relationship between screening and cure of gastric cancer. ［Results］ The cure fraction of subjects who ever participated in screening and subjects who never were 75.51%(95%CI： 69.18%~81.85%) and 31.69%(95%CI： 30.30%~33.07%)， respectively， with an estimated difference in cure fraction of 38.76%(32.35%~45.00%). Compared with patients who never participated in the screening program， the OR of cure in patients who ever participated in screening was 5.84(95%CI： 4.10~8.31). The yielding cure in cardia gastric cancer patients was 6.10(3.96~9.39)，which was higher than that in non-cardia gastric cancer patients ［5.34(2.54~11.23)］. ［Conclusion］ Endoscopic screening for gastric cancer may be related to the improvement of cure fraction in the population. |
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